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73 Indeed, there is evidence suggesting that FGF21 can be expressed and secreted by the heart following cardiac damages such as cardiac hypertrophy, oxidative stress and MI, and exerts its diverse cardioprotective functions in an autocrine manner

(2014) 9:e96464

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413,417 Declining NAD + levels reduced the SIRT1-mediated inhibition of STAT3, which induces the secretion of IL-6 and TFG- to sustain the signaling required for EMT