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Intercellular Na + waves are also generated throughout the astrocyte syncytium, elevating glucose uptake, and metabolism in neighboring astrocytes as well (Bernardinelli et al., 2004

Free Radical Biol Med (2010) 49(11):160316

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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

doi: 10.2174/138945011793591635 58
