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This lactylation in pancreatic cancer cells enhances NMNAT1s enzymatic activity and nuclear localization, resulting in effectively sustained NAD + salvage pathway in the nucleus, preventing the cellular NAD + pool from collapsing under metabolic stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Merza N, Ahmed Z, Nawras M, Dar SH, Itani MI, Al-Hillan A, Zafar Y, Naguib T, Kobeissy AA, Hassan M, Islam A, Alastal Y

Because NNMT intersects NAD salvage, pairing with NMN/NR is a common experimental strategy to test additive or synergistic effects on cellular NAD and metabolic endpoints

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