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An important reality: PIE and PIH can coexist in the same patient and even within the same individual lesion, especially in Fitzpatrick III through V skin (common in Miamis Hispanic and Caribbean population)

Notably, HGF is implicated in guiding spinal motoneurons to their target muscles in the limbs (Ebens et al., 1996)

Pain after BPI can be highly variable and extremely individual

[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Barros M.C.F., Ribeiro A.C.F., Esteso M.A

In addition to clinical procedures such as laser, mesotherapy, and fillers, lifestyle changes such as regular sleep and nutritional supplements play an effective role in the treatment process