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Stephen Sinatra: Basically, if you want to talk about heart failure, when you and I were both in medical school, and were probably around the same age, you probably heard what I heard

Targeting thyroid hormone receptor- agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

doi: 10.1161/01.atv.19.11.2742

doi:10.1080/14647273.2018.1515503

BRPF1 contains a bromodomain, which is reported to bind H2AK5ac, H4K12ac, and H3K14ac (Poplawski et al, 2014), and two PHD fingers closely linked by a zinc knuckle, which bind to unmodified histone H3 tail and nucleosomal DNA (Klein et al, 2016)