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Moreover, trimethylamine oxide and imidazole propionate affect insulin signal transduction by acting on different pathways [136]

Given that the PHD enzymes require O 2 as a substrate for the hydroxylation reaction, when conditions of hypoxia exist the HIF subunits escape hydroxylation and are, therefore, not ubiquitylated

If the 15% of the hemoglobin is in the form of methaemoglobin, the colour of the mucosae and blood can be darker red or brownish in colour

In experimental models of glaucoma, overexpression of BDNF alleviated RGC loss after optic nerve injury and improved RGC survival, but this effect is time-limited because of downregulation of TrkB (the BDNF receptor) [75]

The inhibition of viral replication by an increase in glutathione has been reported for HIV (Garaci, 1997