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Yes, neurological damage from B12 deficiency can become irreversible if treatment is delayed, even though haematological abnormalities typically resolve with supplementation

L-glutathione and L-cysteine may brighten skin and dark spots

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However, performance on this measure across the PAC settings, including the range of HHAs, is so high and unvarying across most HH providers that the measure no longer offers meaningful distinctions in performance