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Probable predisposition and causes of ME/CFS The diverse symptom presentation and patient heterogeneity indicate that ME/CFS is likely to have a multifactorial origin (23, 30, 53, 58), with multiple physiological processes implicated in the pathogenesis (52, 59)

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Wheeler CR, Salzman JA, Elsayed NM et al

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References "Prospective, Preclinical Comparison of the Performance Between Radiofrequency Microneedling and Microneedling Alone," Journal of Cosmetic Dermatology , September 6, 2019