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Description
Ferroptosis is regulated by many aspects of iron metabolism, including iron absorption, transport, storage, and utilization (section 4.1) [17]

Routine clinical pharmacology studies such as SAD, MAD, mass-balance, and DDI studies were not performed in the case of NAC approvals, limiting the available information on the drug, which has been extensively used since the 1960s

Even mild exertion causes a massive leakage of reactive oxygen species, overwhelming the body's depleted antioxidant defenses

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As a chronic disease, most liver injuries need long-term treatment, thus, reducing side-effects of the therapy is critical when developing novel hepatoprotective agents