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GAA administration significantly upregulated the expression of GPX4, SLC7A11, and NRF2 in the hippocampus of APP/PS1 transgenic AD mice, inhibited neuronal ferroptosis, and improved cognitive function in these mice
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Three weeks post pristane administration
A two-way ANOVA followed by Bonferroni post-hoc test was used for comparisons between treatment methods (IP versus ICV) time post injection (Treatment X Time)