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This finding suggests species-specific differences in receptor crosstalk on murine and human DC, as both haloperidol and risperidone have strong affinities for D2-like receptors, but risperidone has much higher affinity for serotonin receptors

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The authors of a 2022 review described the relationship as a vicious cycle: melatonin synthesis decreases as you grow older, and the aging process worsens because of melatonin deficiency

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