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Disruption of endothelial integrity is typically incurred during graft harvesting due to mechanical trauma, and, although also described in free arterial grafts ( Endothelial injury leads to activation of a platelet-mediated thrombotic cascade (Figure 1) ( Antithrombotics in the prevention of graft thrombosis Aspirin Aspirin is a non-selective, irreversible cyclooxygenase inhibitor that prevents downstream prostaglandin and thromboxane A 2 synthesis, thus inhibiting platelet aggregation (Figure 2)

Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the bloodbrain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis

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Some studies included specific subgroups based on age, severity of ASD symptoms, or comorbid conditions
