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For future directions these broader searches may be preferable, for example exploring options for generating polygenic risk scores that enhance GWAS association signals [52] and performing a PheWAS [53] on putative ME/CFS SNPs to elucidate genetic signals shared between other diseases or traits

Cheng J, Huang H, Chen Y, Wu R

doi: 10.1038/nrendo.2012.189 106 AgasheSPetakS

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To overcome these issues, researchers have explored strategies such as multi-target aptamer approaches, which enhance capture specificity by simultaneously recognizing multiple surface markers on EVs