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Age-related microvascular degeneration, characterized by endothelial dysfunction, pathological extracellular matrix remodeling, and loss of vascular elasticity, further compromises microvascular integrity, heightening susceptibility to CMHs that eventually leads to neurological symptoms [17, 23, 27,28,29,30,31]

10.1513/AnnalsATS.201705-370AW 89 RindlisbacherB.SchmidC.GeiserT.BovetC.Funke-ChambourM

Luminescence measurements were taken every 10 minutes for a duration of 24 hours using a GloMAX Discover microplate reader (Promega)

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10.3892/mmr.2016.5785 70 LiuY.GaoJ.PengM.MengH.MaH.CaiP.et al (2018)