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Extracellular HSP90 induces myd88-IRAK complex-associated IKK/ NF-B/IRF3 and JAK2/TYK2 STAT-3 signaling in macrophages for tumor-promoting M2-polarization

In comparison, the 50-mg/kg dose displayed more pronounced effects, increasing them by 103.1% and 77.8%, respectively, in contrast to the TAA group, approaching normal values (Figure 6)

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Additionally, some researchers believed that the spleen might also be one source of islets, with splenic cells potentially differentiating into insulin-producing cells (100)