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[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Jiao L., Bondy M.L., Hassan M.M., et al

No clinical study shows it damages healthy renal tissue, raises creatinine, or causes kidney stones

Supports healthy red blood cell production
Leveraging these enzymes for targeted anti-tumor therapy holds the advantage of precision targeting, minimal damage to healthy cells and reduced toxic side effects, thereby enhancing and reversing tumor drug resistance

DOX can also cause proteins to be excreted in the urine by destroying the nephrons directly
