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The role of phosphorylation in MOR desensitization has been challenged: using staurosporine as a broad spectrum kinase inhibitor and a GRK2-mutant mice, Arttamangkul et al

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The mechanism appears to involve increased serotonin synthesis in substantia nigra, a regional pattern unlike any existing antidepressant drug

doi: 10.1002/jnr.24220

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