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Puspita, L., Chung, S

The recent discovery of a novel mechanism by which FIN56 and FINO2 trigger cellular death provides new insights on the regulation of ferroptosis ( Many traditional Chinese medicinal natural products provide significant health benefits in the prevention and/or treatment of diseases

Notably, pharmacological inhibition of either AMPK or autophagy partially restores cell viability but fails to rescue ATP levels, suggesting that hyperactivated mitophagy consumes residual functional mitochondria, thus perpetuating a deleterious feedback loop 32

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In fact, greater awareness, better research, and more open discussion are long overdue