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2.3 Mechanisms linking gut microbiota dysbiosis to hypothyroidism development Gut microbiota dysbiosis exerts significant impacts on multiple physiological systems, directly and indirectly exacerbating the pathogenesis of hypothyroidism through several interconnected mechanisms
The lipotoxic effects of lipid accumulation include disturbances in metabolism, oxidative stress, mitochondrial dysfunction, proinflammatory signaling and accumulation of lipid derivatives like diacyloglycerol and ceramide [81]
3rd ed : Wiley-Blackwell 2013
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2024;153:487502.e489
