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Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan Sapienza University of Rome, Unit of Rheumatology, Rome, Italy Enrico Arosio, MD, Sergio De Marchi, MD and others

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Specifically, moderate DNA damage stress triggers mitophagy to remove damaged and depolarized mitochondria, while drastic stress is able to induce mitochondrial outer membrane permeabilization and apoptosis [174]

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Two kinds of eukaryotic metal-binding peptidesmetallothioneins and phytochelatinsare high in cysteine residues and bind metal ions via sulfhydryl groups (Pinto et al., 2003)
