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mBio (2022) 13(2):e0325121

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Contraindications: Active malignancy (GH stimulation may accelerate latent tumors), pregnancy, and known hypersensitivity to tesamorelin or mannitol [6]

Stimulating Regeneration and Connectivity (bottom right, orange): Techniques like PTEN inhibition and neuromodulation (e.g., deep brain stimulation or chemogenetics) promote axonal growth and reconstitution of neural circuits

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol