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Continued progress will depend on technologies such as single-cell multi-omics, spatial proteogenomics, intravital imaging of iron flux, and ferroptosis-reporter mouse models, which can resolve these interactions with high precision

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In rodent models, Sema has been shown to activate GLP-1 receptors in the hypothalamus, indirectly affecting TSH (thyroid-stimulating hormone) levels and downstream thyroid hormone regulation

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