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10.1182/blood-2011-05-353995 125 MoranM
Canonically, hormetic effects were attributed to the increased concentration of chaperones inside the cell, but it is now accepted that a more complex scenario takes place
It was previously shown that the acute administration of paclitaxel to neuroblastoma cells in culture increased the binding of the cytoplasmic calcium-binding protein neuronal calcium sensor 1 (NCS-1) to the inositol 1,4,5 tris-phosphate receptor (InsP3R) [35, 36]
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BBB dysfunction is an early pathological feature of AD, contributing to impaired A clearance and increased neuroinflammation
