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[8] The superior BDNF response to paraxanthine may help explain its enhanced cognitive benefits compared to caffeine

[DOI] [PMC free article] [PubMed] [Google Scholar] 223.Tossetta G., Marzioni D

Despite promising results from preclinical investigations, clinical studies often face issues related to poor bioavailability, inconsistent dosing, and methodological variability

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Various enzymes involved in the glutathione system encoded by genes, GSS, GLUL, GSTM1, GSTM5, GSTP1 as well as the thioredoxins ( TXN ) and heme oxygenase1 ( HMOX1 ) contribute to the bodys antioxidant system by maintaining redox homeostasis