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Furthermore, real-world evidence regarding its effectiveness remains mixed

Hoter A, El-Sabban ME, Naim HY

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In innate immunity, Clostridium modulates macrophage polarization (shifting from pro-inflammatory M1 to anti-inflammatory M2), induces tolerogenic dendritic cell phenotypes to suppress excessive antigen presentation, regulates inflammatory body activity and neutrophil hyperactivation, and modulates ILC subsets to reinforce mucosal defense

Signorelli et al., 2015)