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doi: 10.1111/j.1523-5378.2009.00711.x 54 JavaheriA.KruseT.MoonensK.Mejas-LuqueR.DebraekeleerA.AscheC
Until recently, the prevailing hypothesis to explain the age-related NAD decline was that activation of DNA-repair enzymes such as PARPs during the aging process would consume and deplete cellular NAD [1-4]