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Second, it promoted dermal papilla cell proliferation, increasing the population of cells responsible for initiating new growth cycles

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Clinical trials showed modest fat loss of roughly 2-3 kg over 12 weeks, and the compound was never approved as a pharmaceutical because efficacy did not meet the threshold for drug registration (Heffernan et al., 2001)

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Using advanced electrophysiological techniques, optogenetic activation, and chemogenetic silencing approaches, studies reveal tesofensine inhibits a specific subset of LH GABAergic neurons, reducing their ability to stimulate food-seeking behavior and consumption