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Evaluation of the number of sexual lineage cells The optical dissector method was used to determine the total number of cells including spermatogonia, spermatocytes, round spermatids, long spermatids, Sertoli cells, and Leydig cells in 20 m sections (Fig

The mice exhibited reduced fibrotic markers expression, attenuated proinflammatory response, and alleviated EpiC damage, which might be mediated by restoring mitochondrial homeostasis (Miguel et al., 2021)

Effects on testosterone levels and hormone interactions Recent research, including a 2025 meta-analysis, indicates that GLP-1 receptor agonists like semaglutide can elevate bioavailable testosterone levels in men with obesity or type 2 diabetes, with significant increases observed (e.g., mean differences in bioavailable testosterone)

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