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In FM, melatonin has been shown to improve sleep quality, pain levels, and the pain threshold by enhancing the descending endogenous pain-modulating system [63]
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doi: 10.3389/fimmu.2023.1330312

However, these unwanted effects are typically associated with higher doses, typically at least 3 grams per day

10.1016/j.tplants.2004.10.002 [DOI] [PubMed] [Google Scholar] Vogler S., Grosche A., Pannicke T., Ulbricht E., Wiedemann P., Reichenbach A., et al
