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Nevertheless, inactivation of GSTA4 remarkably increases cell susceptibility to chemotherapeutic agents in vitro and in the xenograft mouse model

Cancer immune escape: the role of antigen presentation machinery

D., Van Domselaar, G

These effects contribute to a reduction in fibrosis and the enhancement of repair processes, without compromising the healing response, as demonstrated by decreased paw swelling and improved histological outcomes in rat models [120]

However, GS-4997 completely inhibits the activity and normal function of ASK1 with potential side effects 41,42
