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They work best when combined with other health approaches

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Butler K, Day C, Dietze P, Bruno R, Alati R, Burns L

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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

Damian Holsinger, The University of Sydney, Australia Reviewed by Woo Jung Kim, Yonsei University, Republic of Korea Anna Flavia Cantone, University of Catania, Italy Francesco Amenta, University of Camerino, Italy Updates Copyright 2025 Biggio and Mencacci