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However, after a long period of L-DOPA therapy, results can cause a variety of side effects, including hyperkinesia (unpredictable and uncontrollable movements) and on-off phenomena

10.1042/bj2220001 258 SmithE

In the case of muscle, for instance, IGF1-LR3 does not cause muscle cells to get larger, but it does increase total numbers of muscle cells

Endothelium-dependent vasodilation is impaired in individuals with elevated serum cholesterol concentrations, as well as in patients with coronary heart disease or diabetes mellitus