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FOXO factors maintain this state by regulating cell-cycle genes and controlling glucose and glutamine metabolism, thereby preventing premature proliferation and exhaustion of the NSCs pool

The acid-responsive release of TH588 inhibits MTH1-mediated scavenging of oxidized bases, further aggravating oxidative DNA damage

Some patients get progressively better and after a series of treatments, they no longer require ongoing weekly vitamin therapy, only monthly treatments to maintain balance