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The GSH concentration was not affected in the mucosa at 5% SI and 75% SI and in erythrocytes by adding dietary GSH both on d5 and d14

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New Engl J Med (2004) 351(6):53342

Additionally, these radicals activate transcription factors like nuclear factor B (NF-B) and NRF2, which upregulate genes that support proliferation and enhance cellular antioxidant defenses, consolidating a pro-growth adaptive response

they have to be freely circulating in the tissue, in the fluids, and the bloodstream
