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September/October 2009 Metals, oxidative stress and neurodegenerative disorders Mol Cell Biochem 2010 Dec

Psychiatry 69 (1), 4248

Transitioning from weight loss to maintenance Determining goal weight achievement: Lost 10-12% body weight (cagrilintide alone) Lost 15-25% body weight (CagriSema) Weight stable for 4-8 weeks Satisfied with current weight Ready to focus on maintenance Maintenance dose options comparison: Option 1: Continue same dose Keep cagrilintide at 2.4mg weekly Ensures no regain Most conservative approach Highest cost Option 2: Reduce dose slightly Decrease to 1.8-2.0mg weekly Monitor weight for 4 weeks If stable, maintain If gaining, increase back 20-25% cost savings Option 3: Try every 10 days Instead of weekly, inject every 10 days Effectively 30% dose reduction Some maintain weight this way Requires close monitoring Recommendation: Try Option 2 first (reduce to 1.8-2.0mg)

Moreover, multiple in vitro (64,65) and in vivo (66,67) studies suggest that ergothioneine activates the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which triggers the cellular antioxidant defence system

Automated mechanical devices delivering both insulin and glucagon to replace the islet are near at hand, but require much refinement to be reasonable approaches for type 2 diabetes care [10]