discovery of glutathione - an overview The Biological Functions of Glutathione

GBM 2012.2 displayed 4- and 2-fold higher glucose-derived synthesis of serine and glycine, respectively, compared to GBM 1919, which showed low levels of baseline ser/gly synthesis, suggesting dependency on serine and glycine uptake (Fig

89 ZhuY.LiuY.ZhangC.ChuJ.WuY.LiY.et al (2018)

To address this gap, we developed a clinically relevant mouse model of CMHs by inducing chronic hypertension in aged mice using angiotensin II (Ang II) and the NO synthase inhibitor N()-nitro-l-arginine methyl ester (L-NAME) [17, 18, 33,34,35,36]

doi: 10.1002/path.5351 93 GuS.XuM.ChenL.ShiX.LuoS.-Z

In this model, excess ROS plays a role in decreasing the expression of PKC II, as overexpression of GPx1 increases PKC II expression and ERK1/2 activation