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The compact and symmetric structure of rosmarinic acid (Table 1) binds specifically to A, inhibits polymerization into the fibrillar form, and inhibits tau aggregation [170,173], imparting protection in AD and other neurogenerative conditions

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This prevents foaming and potential damage to the delicate peptide structure

When germ-free mice were exposed to constraint stress, they exhibited a stronger stress response compared to normal mice, with significant increases in adrenocorticoid and glucocorticoid levels

Wu X, Hammer JA