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New ERT therapies are emerging that provide sustained plasma concentrations, such as Pegunigalsidase (134)

Definitive determination of PNDM requires early gene screening as soon as symptoms manifest

The colocalization of GPX4 with neuromelanin could indicate a response to oxidized lipids associated with neuromelanin

blood sugar should be monitored as GH can affect insulin sensitivity

doi: 10.1152/physrev.00011.2005
