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doi: 10.1038/s41398-021-01571-9

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However, these 2D models fail to fully reproduce the unraveling complexity of the BBB, and there is still a need for accurate and physiologically relevant BBB models to facilitate the translation of nanomedicines for the treatment of CNS diseases from the laboratory to clinical applications

It must be added that ozonated erythrocytes show an improved glycolysis with an increase of ATP and 2,3-DPG levels, which are able to shift the dissociation curve of HbO 2 to the right, confirming the observation of an improved delivery of oxygen in peripheral obstructive arterial disease