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Impaired Ca 2+ homeostasis can affect migration, proliferation, Purkinje cell development, dendritic arborization, synapse formation, and maintenance [94]

The subsequent antigen presentation triggers the activation of Th1 and Th17 cells, leading to the release of pro-inflammatory cytokines (IL-2, TNF-, IFN-, IL-17), which in turn amplify oxidative stress and perpetuate an amplifying loop of inflammation and tissue damage (Kubiak et al

[DOI] [PubMed] [Google Scholar] 57.Bushweller JH, Aslund F, Wuthrich K, Holmgren A

Although HCC is the most severe complication of liver cirrhosis within the MASLD spectrum, it can also develop in patients with MASH even in the absence of overt cirrhosis [22]

Promoting such ecological constructs will reduce the use of pesticides, improve the output and quality of A