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Incorrect dilution means incorrect dosing, and incorrect dosing means either subtherapeutic effects or unnecessary side effects

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Rarely, fluid retention is refractory to diuresis and discontinuation of minoxidil is required

These can be the upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, altered NMDA receptor expression, altered dendritic morphology [167,168], and altered functioning of cholinergic (ACh-ergic) basal neurons, projecting to the cortex [169] by repeated exposure to amphetamine (amphetamine-induced sensitization)