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In 3T3-L1 cells, expression of TGH is upregulated tenfold upon differentiation of preadipocytes into adipocytes (25) due, at least in part, to transcriptional regulation by the adipogenic transcription factor C/EBP (136)

Full-range protocols (0.25mg to 2.5mg) For protocols that escalate through the full dose range, 2.5mg/mL is the goldilocks concentration

In the basal state PNPLA2 has weak hydrolytic activity which is greatly increased by the co-lipase alpha/beta hydrolase domain-containing protein 5 (ABHD5, also known as CGI-58) by greater than 20-fold (30)