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Flare of autoimmune hepatitis causing acute on chronic liver failure: diagnosis and response to corticosteroid therapy
Moreover, NRF2 induces the gene expression of SESN2 and PINK1 to promote macroautophagy and mitophagy in the cell response to oxidative stress, respectively [121, 122]
This is an irreversible reaction, catalyzed by glucose-6-phosphate dehydrogenase (G6PDH, a rate-limiting enzyme of this pathway), while inhibited by NADPH feedback
10.1016/s0021-9258(19)39423-2 80 TrseidM
doi:10.1177/2331216515580272 9
