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The presence of IgG3 has also been found to predict the treatment response to IVIg, which is thought to work at least partly by saturating FcRn and thereby preventing endogenous IgG from being salvaged from degradation [163, 164]

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Blinding ensures that the researchers cannot influence the outcome by consciously or unconsciously favoring one group over the other

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Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM, Investigators RA

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