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GSH and GSSG recycling occurs via GPx and glutathione reductase, a process integral to regulation of ferroptosis, emerging as a contributor to neuronal death after TBI [45] and hemorrhagic stroke in mice [46]

Here, the authors determined all rate constants of the reaction cycle for roGFP2 measurements and identified an alternative glutaredoxin mechanism

Ferroptosis in CD Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation that causes direct plasma membrane damage

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