glutathione-s-transferase code biochem RCSB PDB Frontiers | Glutathione S-Transferase Enzymes

By modulating critical pathways (e.g., AKT/mTOR, JAK/STAT, and NRF2) in tandem with Tregs, MDSCs, and fibroblasts, it dampens tumor progression while enhancing chemotherapy responsiveness

The development of epigenetic therapies shows considerable promise, particularly through the use of inhibitors targeting enzymes that regulate epigenetic modifications, such as DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), which have exhibited promising radioprotective effects (69)

Wang ID, Tsai P-Y, Peng C-K, et al

Molecular brain research

More importantly, clinical research data have not observed that DPP1 inhibitor treatment significantly increases serious infection risks, supporting the conclusion that DPP1 inhibition has relatively limited impact on host defense functions within therapeutic dose ranges (Zhong et al., 2025