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Description
Specific polyphenolic compounds, omega-3 fatty acids, and vitamins activate neurotrophic signaling pathways (PI3K/Akt and MAPK/ERK), which result in the phosphorylation of the transcription factor CREB required for expression of the BDNF gene (Figure 2)

In simple terms, the molecules become less likely to stick together, which can help the peptide move into a clearer and more uniform solution

Potential calming of neuroinflammatory processes driving pain sensitization

Normalized bigWig files, scaled to 1 million mapped reads, were generated using BEDTools

& Carpenter, J
