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This relationship constitutes the GH-IGF-1 axis, which has important roles in glucose and lipid metabolism 4 , body composition 5,6 , aging 7 and malignancy development 8

The endogenous-acetylcholine-induced VEGF expression in neurons and astrocytes [302], the VEGF signaling system is in the rescuing effect of acetylcholine on NMDA-induced long-lasting hippocampal cell damage [303]

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