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91 Interestingly, by performing a CRISPR-Cas9 knockout screen using a focused library of epigenetic regulators, CDK5 was identified as a sensitizer to DHODH inhibition, thereby raising the possibility of simultaneously targeting different mitochondrial processes

Microcirculation There are some structural peculiarities of blood vessels in the CNS that have a bearing on the development of pathologic processes

Mitochondrial DNA damage and repair in neurodegenerative disorders

The integration of these three approaches at the level of the same sample will become an important direction for advancing this field from mechanistic research toward clinical translation (140)

Glutathione reduced and L-glutathione refer to the same compound, indicating the active and natural form of glutathione