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Among these, CVDs represent the leading cause of mortality among the elderly ( Figure 1 In the cardiac environment, aging emerges as a stress response triggered by numerous stimuli, such as telomere attrition, virus infection, hypoxia, oxidative stress, mitochondrial dysfunction, protein imbalance, and impaired autophagy ( This manuscript discusses the phenotypic expressions and underlying molecular pathways correlated with the ageing process and their contribution to the development of CVDs

Activation of the NF-B pathway further promotes NLRP3 transcription and inflammatory cytokines such as TNF- and IL-6, impairing renal vascular cells [76, 114]

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